Optic nerve head biomechanics in aging and disease
نویسندگان
چکیده
منابع مشابه
Factors influencing optic nerve head biomechanics.
PURPOSE The biomechanical environment within the optic nerve head (ONH) may play a role in retinal ganglion cell loss in glaucomatous optic neuropathy. This was a systematic analysis in which finite element methods were used to determine which anatomic and biomechanical factors most influenced the biomechanical response of the ONH to acute changes in IOP. METHODS Based on a previously describ...
متن کاملBiomechanics of the optic nerve head.
Biomechanical factors acting at the level of the lamina cribrosa (LC) are postulated to play a role in retinal ganglion cell dysfunction and loss in glaucoma. In support of this postulate, we now know that a number of cell types (including lamina cribrosa cells) are mechanosensitive. Here we briefly review data indicating cellular stretching, rate of stretching and substrate stiffness may be im...
متن کاملCollagen microstructural factors influencing optic nerve head biomechanics.
PURPOSE Previous studies have suggested that the lamina cribrosa (LC) and its surrounding sclera are biomechanically important in the pathogenesis of glaucoma, but many were limited by assumptions of tissue isotropy and homogeneity. Here, we used an improved biomechanical model driven by experimental measurements of scleral and LC collagen fiber organization to more accurately evaluate optic ne...
متن کاملCerebrospinal Fluid Pressure: Revisiting Factors Influencing Optic Nerve Head Biomechanics
Purpose To model the sensitivity of the optic nerve head (ONH) biomechanical environment to acute variations in IOP, cerebrospinal fluid pressure (CSFP), and central retinal artery blood pressure (BP). Methods We extended a previously published numerical model of the ONH to include 24 factors representing tissue anatomy and mechanical properties, all three pressures, and constraints on the op...
متن کاملFinite element modeling of optic nerve head biomechanics.
PURPOSE Biomechanical factors have been implicated in the development of glaucomatous optic neuropathy, particularly at the level of the lamina cribrosa. The goal of this study was to characterize the biomechanics of the optic nerve head using computer modeling techniques. METHODS Several models of the optic nerve head tissues (pre- and postlaminar neural tissue, lamina cribrosa, central reti...
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ژورنال
عنوان ژورنال: Experimental Eye Research
سال: 2015
ISSN: 0014-4835
DOI: 10.1016/j.exer.2015.02.011